Michael Otto Selected Research

Staphylococcal Infections

1/2018	Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection.
5/2015	Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.
1/2015	Quorum-sensing regulation in staphylococci-an overview.
10/2014	Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.
8/2014	Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection.
7/2014	Phenol-soluble modulins--critical determinants of staphylococcal virulence.
10/2013	Phenol-soluble modulins and staphylococcal infection.
6/2012	The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.
1/2012	Enterococcus faecium stimulates human neutrophils via the formyl-peptide receptor 2.
7/2010	Novel targeted immunotherapy approaches for staphylococcal infection.

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Michael Otto Research Topics

Disease

66	Infections 03/2022 - 09/2003
12	Staphylococcal Infections 01/2018 - 01/2008
10	Sepsis (Septicemia) 01/2021 - 01/2004
7	Bacterial Infections (Bacterial Infection) 01/2018 - 12/2008
6	Bacteremia 03/2022 - 07/2004
5	Inflammation (Inflammations) 11/2018 - 07/2009
4	Abscess 01/2022 - 12/2006
4	Soft Tissue Infections 03/2016 - 07/2004
4	Staphylococcal Pneumonia 01/2016 - 12/2007
3	Pneumonia (Pneumonitis) 01/2016 - 02/2008
2	Pain (Aches) 01/2018 - 10/2010
2	Skin Diseases (Skin Disease) 11/2013 - 04/2011
2	Neoplasms (Cancer) 09/2013 - 01/2012
2	Hemolysis 04/2012 - 05/2008
1	Dehydration (Water Stress) 01/2022
1	Otitis 01/2022
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2019
1	Staphylococcal Food Poisoning 01/2018
1	Melanoma (Melanoma, Malignant) 01/2018
1	Foodborne Diseases 01/2018
1	Hyperalgesia 01/2018
1	Central Nervous System Infections (Central Nervous System Infection) 01/2017
1	Hyperlipidemias (Hyperlipidemia) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2016
1	Breakthrough Infections 04/2015
1	Acute Disease 01/2015
1	Cellulitis 03/2014
1	Mycoses (Diseases, Fungus) 03/2014
1	Epidural Abscess 03/2014
1	Body Weight (Weight, Body) 01/2014
1	Dermatitis 11/2013

Drug/Important Bio-Agent (IBA)

18	Anti-Bacterial Agents (Antibiotics)IBA 03/2022 - 12/2007
14	Peptides (Polypeptides)IBA 11/2017 - 09/2003
9	Phenol (Carbolic Acid)FDA Link 01/2019 - 01/2004
8	Panton-Valentine leukocidinIBA 11/2016 - 12/2007
7	CoagulaseIBA 01/2017 - 01/2004
6	Pharmaceutical PreparationsIBA 01/2021 - 01/2008
5	VaccinesIBA 12/2021 - 01/2008
5	Antimicrobial PeptidesIBA 01/2018 - 03/2005
5	staphylococcal delta toxinIBA 11/2017 - 09/2011
4	Virulence Factors (Pathogenicity Factors)IBA 01/2016 - 03/2012
4	AntibodiesIBA 06/2012 - 01/2008
3	Surface-Active Agents (Surfactants)IBA 11/2018 - 01/2011
3	Hemolysin Proteins (Hemolysins)IBA 01/2018 - 12/2007
3	CytokinesIBA 01/2017 - 04/2010
3	Methicillin (Metin)FDA Link 03/2016 - 02/2012
3	Proteins (Proteins, Gene)FDA Link 10/2014 - 01/2013
2	Vancomycin FDA LinkGeneric 01/2016 - 01/2014
2	Carrier Proteins (Binding Protein)IBA 02/2015 - 10/2012
2	AntigensIBA 11/2013 - 01/2008
1	Early Growth Response Protein 1IBA 01/2022
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2022
1	CeramidesIBA 01/2022
1	staphylococcal enterotoxin BIBA 01/2021
1	InflammasomesIBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Histones (Histone)IBA 01/2019
1	CationsIBA 01/2018
1	EmeticsIBA 01/2018
1	Enterotoxins (Enterotoxin)IBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 01/2018
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2018
1	Adenosine Monophosphate (AMP)IBA 01/2018
1	Sodium Channel BlockersIBA 01/2018
1	QX-314IBA 01/2018
1	Leukocidins (Leukocidin)IBA 01/2018
1	Lidocaine (Xylocaine)FDA LinkGeneric 01/2018
1	Interleukin-17 (Interleukin 17)IBA 11/2017
1	AlarminsIBA 11/2017
1	Guanosine TetraphosphateIBA 10/2016
1	GTP-Binding Proteins (G-Protein)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Toll-Like Receptor 2IBA 01/2016
1	Lipoproteins (Lipoprotein)IBA 01/2016
1	Investigational DrugsIBA 05/2015
1	Membrane Proteins (Integral Membrane Proteins)IBA 05/2015
1	FibrinIBA 02/2015
1	Fibrinogen (Factor I)FDA Link 02/2015
1	Fibronectins (Fibronectin)IBA 02/2015
1	Cystine (L-Cystine)IBA 10/2014
1	Nerve Growth Factor (NGF)IBA 10/2014
1	savirinIBA 06/2014
1	Methylprednisolone FDA LinkGeneric 03/2014
1	TitaniumIBA 01/2014
1	enhanced green fluorescent proteinIBA 01/2014
1	Cefazolin (Ancef)FDA LinkGeneric 01/2014
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2014

Therapy/Procedure

11	Therapeutics 03/2022 - 01/2012
9	Catheters 01/2012 - 09/2007
2	Injections 03/2014 - 01/2012
2	Palliative Care (Palliative Therapy) 09/2013 - 01/2012
2	Immunotherapy 07/2010 - 01/2008
1	Oral Administration 11/2021
1	Intravenous Injections 01/2018
1	Investigational Therapies (Experimental Therapy) 05/2015
1	Operative Surgical Procedures 04/2015
1	Arthroplasty 04/2015
1	Antibiotic Prophylaxis 04/2015
1	Epidural Injections 03/2014
1	Debridement 03/2014